How To Mix and Inject HCG With TRT - Balance My Hormones TRT in the UK
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How To Mix and Inject HCG With TRT

How To Mix and Inject HCG With TRT

By Mike Kocsis | 3 minutes read | Last updated: September 27, 2025   Categories:   Testosterone

Medically Reviewed by Dr. George Touliatos

Evidence Based Research

Mixing and injecting HCG with TRT is easy when you follow the right steps. Reconstitute the HCG powder with the provided bacteriostatic water, draw up the prescribed dose and inject it subcutaneously in the lower abdomen, thigh or upper arm.

Check out the step-by-step guide and clear video provided below for the full demonstration.

How to mix HCG?

Here is how you can mix HCG powder:

  1. Clean your table surface and prepare the area, along with washing your hands and ensuring you have a sharps bin available. Ensure you have the correct syringes available, in this example, we use a 2ml.
  2. Ensure you have a needle filter ready and alcohol wipes.
  3. The box comes with 3 separate vials, simply pull out one and discard the sterile water provided in the box.
  4. Prepare the needle and syringe by peeling back the packaging without touching the needles, then attaching the filter needle to the syringe by screwing them together.
  5. Get the ampule and snap it away from yourself like you are breaking a Kit Kat open. Put your thumb on the red dot of the ampule and hold the base with the other hand and snap it open.
  6. Take your 2ml syringe with the needle filter and remove the cap of the needle, then place the needle into the open ampule and take out a bit more than 2ml of the saline fluid we supplied you with.
  7. Snap open the HCG protected seal vial and wipe the top with an alcohol swab.
  8. Take your 23-gauge needle and replace the other needle used to get the saline fluid into the syringe, and ensure you have 2ml of fluid in the syringe.
  9. Push the needle into the centre of the vial and slowly push the sterile saline into the vial with the HCG.
  10. Release the pressure on your thumb and the air will be removed from the vial. Discard the syringe and needle in the sharps bin.
  11. Gently swirl (don’t shake) the vial until the HCG powder is completely dissolved and the mixture/solution is clear.

 

How to inject HCG?

HCG is injected subcutaneously as explained below:

  1. Clean and wipe the injection area and open your new syringe, removing the cap and place the needle in the middle of the mixed vial.
  2. Flip the vial upside down and remove to the 50mark or half a ml mark, ensuring you get all the bubbles out of the syringe. Tap on the needle to ensure all bubbles are removed and adjust as necessary.
  3. Pinch the area of skin and use the right injection techniques to administer HCG. Insert the needle at 45 degree angle, simply inject and depress the needle. Discard in the sharps bin and clean your area.
  4. Take your HCG and store it in the fridge.

 

Watch the full How to Mix and Inject HCG video here:

HCG mimics the LH hormone secreted by the pituitary gland to stimulate internal testosterone production. It works with the FSH in the testicles to support fertility.

Its administration offers many benefits to low T patients, such as improved libido, fertility, cognitive function and overall quality of life. Here is how you can mix and inject it the right way:

How often to take HCG on TRT?

HCG injection frequency can vary based on your needs. Mostly, it is recommended to take HCG 2 to 3 times per week, like on Monday and Thursday or on Monday, Wednesday and Thursday.

 

How much HCG should I take with TRT?

Human chorionic gonadotropin dosing depends on your individual needs, such as whether you need it to enhance fertility, testicular size, testicular function or your current testosterone levels.

Typically, 500 IU or less is recommended for maintenance of testicular function and 500 IU or above is prescribed for fertility support.

Talk to your doctor for dosing instructions that suit your specific hormone and health requirements. Always maintain your dosage as directed by your healthcare provider.

 

Where do I inject HCG?

HCG medication is given as a subcutaneous injection. Its most common injection sites are:

  • Back of the upper arm
  • Lower abdomen
  • Outer thigh or front of thigh

 

Should I take HCG with TRT?

Whether you should take HCG hormone with TRT or not depends on your specific goals and needs. Opt for this option if you have hypogonadism and want to:

  • Preserve your fertility/prevent male infertility that’s a common side effect of TRT
  • Prevent testicular atrophy
  • Maintain/stimulate production of natural testosterone by Leydig cells while having testosterone replacement therapy

 

Book your free consultation with one of our professionals to discuss HCG and TRT treatments for your hormonal needs.

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Evidence Based Research

This article has been researched and written based on scientific evidence and fact sheets that have then been crossed checked by our team of doctors and subject matter experts.

References, sources and studies used alongside our own in-house research have been cited below, most of which contain external clickable links to reviewed scientific paper that contain date stamped evidence.

Our team of healthcare experts and GMC registered doctors are licensed to UK GMC standards. We strive to provide you with the latest evidence based, researched articles that are unbiased, honest and provide you with accurate insights, statistics and helpful information on the discussed topic to ensure you gain a better understanding of the subject. You can read more about our Editorial Process by clicking here.

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About the Author: Mike Kocsis

Mike KocsisMike Kocsis has an MBA with a focus on healthcare administration and is an entrepreneur and medical case manager for Balance My Hormones which offers medical services in the UK and Europe. Mike has over 20 years of experience in the healthcare sector, much of that working with people who have hormone imbalances. Mike has appeared on podcasts and radio and is an expert speaker on the subject of hormone imbalance. He specialises in Testosterone Replacement Therapy and Hormone Replacement Therapy (HRT) and has helped thousands of people suffering from hormone imbalances recover and regain control of their lives. You can follow him on LinkedIn and on the Balance My Hormones YouTube Channel.

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Last update: September 27th, 2025

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