- What is Testosterone?
- What does testosterone do for a man?
- What does testosterone do for a woman?
- What’s the difference between Menopause and Andropause?
- What testosterone treatment is there for women?
- Do women need testosterone?
- Can women have testosterone treatment as part of their HRT (hormone replacement therapy)?
- What is TRT (testosterone replacement therapy)?
- What is TOT (Testosterone Optimisation Therapy)?
- Are Testosterone levels dropping? Are Testosterone levels in men dropping over subsequent generations? Were my father’s testosterone levels higher than mine at a similar age?
- Is TRT always necessary/needed?
- What are common signs of low testosterone levels?
- How your body regulates testosterone is through the hypothalamic gonadal axis (HTPA or HPGA)
- What types of low testosterone are there?
- What are the average mens testosterone levels in UK?
- What causes low testosterone?
- Testicular issues that can cause low Testosterone
- Other Causes of low testosterone
- Environmental Causes of Low Testosterone and Endocrine Disrupting Chemicals (EDCs)
- Types of endocrine disruptors (EDCs)
- Is testosterone safe?
- Does TRT cause prostate cancer?
- Does TRT increase risk of heart attack/stroke?
- Will TRT cause my prostate to grow?
- Will TRT cause hair loss?
- Will TRT cause my balls/ testes/(testicles) to shrink ?
- Will TRT cause my penis to shrink?
- Will TRT make my penis bigger?
- What are the side effects of TRT?
- Are there alternatives to TRT
- Does TRT cause infertility?
- Can I maintain fertility on TRT
- Can I take HCG on it’s own
- HOW CAN I FIND OUT IF I AM FERTILE
- DO I HAVE TO STOP TAKING TESTOSTERONE IF I WANT TO HAVE A BABY (can I have a baby whilst on TRT)?
- Does TRT or HRT have an antiageing effect?
- Can TRT help grow my facial hair?
- Does TRT help build muscle?
- Does TRT help with fatigue?
- Does TRT cause man boobs (gyno)(gynocomastia)(bitch tits)?
- Can trt improve interest in sex (libido)?
- What blood tests are needed for TRT in the UK
- How much does TRT cost in the uk?
- How do I get trt in the UK with the NHS?
- How do I get TRT on the NHS? Will my GP prescribe TRT in the uk?
- How to get private TRT in the UK and Europe?
- Will Brexit affect getting TRT in the UK?
- Do I have to be on TRT for life?
- What happens if I stop TRT? What happens if I need to come off TRT?
- What if I can no longer afford treatment?
- What is the best type of TRT in the UK and Europe?
- Injectable Testosterone Preparations
- Bespoke bio-dentical topical testosterone for HRT and TRT
- Are higher doses of testosterone Dangerous?
- Should Testosterone Replacement Therapy be offered on the NHS ?
- How do I administer TRT and do I have to inject on TRT?
- Are there famous people or celebrities on TRT and hormone therapy?
- Joe Rogan discusses his long term use of testosterone replacement therapy on his podcasts and invites others to share their experiences.
- Dorian Yates on TRT- former bodybuilder discussed the benefits of optimal testosterone on health for ageing men.
- Is TRT the same as anabolic steroids?
- How is low T (testosterone) diagnosed?
- How can I stop high oestrogen(estrogen) on TRT
- How is HCG used with TRT?
- How quickly does TRT work?
- What changes will I expect on TRT?
- What happens if TRT doesn’t help/work?
- Can I cycle TRT?
- Can I take TRT with other medications?
- Will TRT help with depression?
- Will TRT help anxiety?
- Can I have TRT with antidepressants?
- Is there a link between low testosterone and dementia?
- What is prolactin?
- What causes high prolactin?
- Can elevated prolactin affect my sex drive and ED (erectile dysfunction)?
- Can TRT help with my ED (erectile dysfunction)?
- What is Pro-Viron® (PROVIRON) used for?
- Has Proviron been discontinued?
- Would it be possible to proceed without the addition of proviron to my treatment? How can I lower SHBG?
What is Testosterone?
Testosterone is known as the male sex hormone. It is is found in men and women and both require it. Men produce around 5-10mgs per day and Woman produce testosterone in much smaller quantities. Despite this lower production it is still very important for women to have an adequate amount, usually in the range of 0.5-3 nmol/l. Men require much higher levels around 20-30 nmol/L for optimum health.
What does testosterone do for a man?
Testosterone is not only important for sexual and reproductive development but plays a huge role in health and longevity. In fact testosterone has an anti-ageing effect . Testosterone is required for cognitive function, sex drive, energy, muscle mass, fertility, bone density and mood amongst other very important bodily functions.
What does testosterone do for a woman?
Oestrogen is the predominant sex hormone in women as testosterone is the predominant sex hormone in men. Both men and women need Testosterone and Oestrogen and if lacking either can experience unpleasant symptoms
In women Testosterone is produced in the ovaries and a smaller amount is produced from the adrenal glands. Testosterone is important for both men and women to improve and maintain bone density, lean body mass, mood, energy, drive and libido. If lacking Testosterone some of, if not all, these symptoms can occur.
What’s the difference between Menopause and Andropause?
Men as they age have a more gradual onset of diminished hormone activity despite remaining still fertile. This is usually referred to as Andropause. Testosterone deficiency is also often accompanied by oestrogen deficiency and men can also experience bone loss as well as women. Men need to have an adequate amount of oestrogen although in a much smaller quantities . Levels of around 100 pmol/L are often ideal for a man.
Women as they age will reach a point of diminishing fertility and produce less oestrogen, progesterone and to a certain degree testosterone. This time usually starts in the early to late 40s is referred to as menopause (there are rarer cases of it happening earlier in life). Women and men require hormones to be balanced and this includes optimal levels of testosterone.
What testosterone treatment is there for women?
Women need testosterone too in doses less than men but it is important all the same. Treatment for women include bio-identical Testosterone in a cream, or sublingual lozenge or troche. It is recommended to be used in combination with oestrogen or progesterone in the correct balance in menopausal and post menopausal women.
Do women need testosterone?
Women like men need testosterone. Testosterone in woman is very important and insufficient levels can cause body fat to increase, cause low mood and anxiety, reduce sex drive, cause brain fog and reduce recovery from physical activity. If testosterone is low in women the doctor will offer treatment ensuring balance with other hormones. When women have their hormones optimised they often feel relief of the above symptoms and this greatly improves quality of life.
Can women have testosterone treatment as part of their HRT (hormone replacement therapy)?
Normally peri-menopausal women or menopausal women can benefit from TRT along with bio-identical HRT. It’s important to get the right balance between Oestrogen,Testosterone and progesterone in women. This is done through treatment and monitoring of blood levels and symptoms.
What is TRT (testosterone replacement therapy)?
Testosterone Replacement Therapy is the medical treatment of a patient that provides restoration of testosterone levels back to a optimal physiological range. It is used to treat symptoms that arise from having insufficient levels of testosterone in the body. It involves providing the body with bioidentical (the same as the body normally produces) testosterone to provide an increase in levels and provide relief of these symptoms. The way in which this is done is personal and unique needs to be monitored to ensure hormones associated with testosterone are also balanced (such as Oestrogen)
What is TOT (Testosterone Optimisation Therapy)?
Testosterone Optimisation is a recent term for describing optimal testosterone therapy and first appeared in Jay Campbell and Jim Brown’s 2018 #1 rated book on Amazon called THE TESTSOSTERONE OPTIMIZATION THERAPY BIBLE, THE ULTIMATE GUIDE TO LIVING A FULLY OPTIMIZED LIFE.
The average testosterone level or “normal range” for men is shifting to lower levels than in previous generations (see below). It is not ideal to merely replace one’s low blood levels of endogenous testosterone( testosterone made by a man’s testes) with a dose of exogenous testosterone that provides similar low levels.
Are Testosterone levels dropping? Are Testosterone levels in men dropping over subsequent generations? Were my father’s testosterone levels higher than mine at a similar age?
A retrospective study done in 2007 in the United States demonstrates that men in previous generations had significantly higher levels of testosterone than men today or at least around 2007 time period in the USA. The study looked at median testosterone for age ranges in 3 different groups in certain time periods. When looking at median ages, the men during the 1987 time period had the higher levels. There seems to be a a trend over the 3 observational groups. Those aged 45-80 years old in the time period 1987 to 1989 had significantly higher levels of Total Testosterone than those measured in the same age range from 2002 to 2004.
The average and median testosterone levels are dropping. What does this mean? Are men evolving to require less testosterone? This is doubtful. The researchers couldn’t pinpoint the exact reason for this significant drop. There is some speculation around increased obesity levels as a cause but is it the low testosterone causing the obesity or obesity causing the low Testosterone?
In any case the evidence is clear that men today have less testosterone than those from previous recent generations. Testosterone Replacement Therapy can help tip the balance back in favour of optimal levels and lower the prevalence of symptoms caused by Low T.
Testosterone levels are also decreasing in Europe and not just he USA. A danish study look at levels of testosterone compared to their fathers. They found after looking at 5000 Danish men born in the 1960s to have 14% lower levels of testosterone compared to their fathers who were born in the 1920s. The very essence of what makes a man a man is on the decline. Worldwide we are seeing an increase in testosterone therapy provision to counter this.
Is TRT always necessary/needed?
Testosterone replacement therapy (TRT) is NOT ALWAYS needed. Occasionally there are ways to boost border line testosterone levels without actually shutting down the pituitary axis. Younger patients can be assessed for testosterone boosting protocols prior to full TRT.
During investigation of your hormones levels you must be screened for other possible causes of symptoms. This involves comprehensive blood testing. As previously mentioned there are other medical treatment options, that can improve testosterone levels, prior to considering full TRT but not everyone is a candidate. Our Medical facilitators and Doctors can help with your patient intake and understanding of what options are available. Please call to discuss various options. If you are suitable for TRT then recipients often notice fast, dramatic positive improvements in symptoms and quality of life.
What are common signs of low testosterone levels?
Men and Women:
- increased body fat
- decreased muscle mass
- brain fog
- loss of height
- loss of confidence
- sleep disturbances
- inability to stay asleep
- sleep apnea
- Low sex drive (libido)
- Difficulty concentrating
- lack of morning erections
- lack of energy
- Weak Erections
- inability to maintain an erection
- frequent urnination at night
- Erectile dysfunction.
- Body and facial hair loss.
- Pelvic floor pain
- How does the body produce testosterone?
How your body regulates testosterone is through the hypothalamic gonadal axis (HTPA or HPGA)
A good analogy is to compare it to a heating system in a house. The temperature is your level of testosterone. The control centre/thermostat is your hypothalamus/pituitary.
The body wants the testosterone level (or temperature) to be kept at a good level.
The LH/FSH (Gonadatrophin releasing hormones) not only tells the testicles to produce testosterone but also sperm. When the cells in the testicles are stimulated it allows testicular size to be maintained . Without this signal, which can be blunted by taking testosterone alone, then the activity of the Leydig cells can lower and sometimes cease. When this happens testicular atrophy can become apparent. This can be prevented using HCG or recombinant LH and FSH as an adjunct whilst on male testosterone replacement therapy.
What types of low testosterone are there?
Low testosterone is referred to as:
- androgen insufficiency
- Age-related testosterone deficiency- 30-60% of men in their 70s are deficient in testosterone. (Wang, C., et al., “ISAm ISSAm, EAU, EAA, and ASArecommendations: investigation, treatment and monitoring of late-onset hypogonadism in males,”Aging Male 2009; 12:5-12.)
- Andropause- “Absolute or relative insufficiency of testosterone or its metabolites in relation to the needs of that individual at that time in his life. “Carruthers, M., “The diagnosis of androgen deficiency,”Aging Male 2002; 4:254.
- Testicular insufficiency
The types of low testosterone recognised clinically are:
- hypogonadotropic hypogonadism
- also called secondary hypogonadism as the pituitary doesn’t produce enough gonadotrophin (LH and FSH) to make adequate testosterone from the testes.
- hypergonadotropic hypogonadism
- also called primary hypogonadism as this is a case of testicular dysfunction where gonadotropin are elevated (LH and FSH) but the output of the testes in making testosterone is sub-optimal.
- isolated hypogonadotropic hypogonadism
- also knows as Idiopathic hypogonadism or congenital hypogonadism including Kallmann syndrome which may also present with accompanying loss of smell. Idiopathic hypogonadism is usually due to a lack of or insensitivity to gnRH or gonadotropin releasing hormone which stimulates the release of LH and FSH.
What are the average mens testosterone levels in UK?
The average man’s testosterone level can vary. We know from lab reference ranges that the levels are anywhere from 8nmol/L to 32nmol/L. It’s quite a large range which doesn’t delineate between those who are truly deficient and those who are optimal. Falling within the range does not mean that you are not without testosterone deficiency and certainly does not necessarily mean you are optimal. The lab reference ranges are intended to be a guide. The ranges are usually developed by the labs and includes sick as well as healthy patients. It defies logic that those who fall outside of the range are deemed as not having testosterone issues and are told they are not candidates for treatment from the traditional sickness focused health care models in Europe and the UK’s NHS. Many men and women suffer needlessly as they are told it’s just in their head.
- 25-29yo average male has a total testosterone level of 23.2nmol/L
- 25-290yo 95th percentile male has a total testosterone level 32.8nmol/L
What causes low testosterone?
When assessing someone for low testosterone one must look at their total and free levels. and not just their total alone. These can be can compared to the laboratory Reference ranges but doing this does not tell the whole story. Reference ranges merely combine all patient data from tests that have been taken. This includes everyone from all ages, quality of life, medical backgrounds and lifestyle factors.
This will include co-morbidities like diabetes and cardiac disease, people from all walks of life with good and bad diets, no alcohol intake to high levels of alcoholism, drug use or smokers. These laboratory ranges do not reflect optimised health range and should not be used to determine if one needs TRT. Experiencing symptoms primarily and a comparison of your hormone levels to the average range of a healthy 20 year old is the preferred way to determine if you are optimal and if TRT may be required. Time of day can also influence testosterone levels. Levels taken at the end of the day may appear lower than when taken in the morning.
Medical laboratories define low TOTAL testosterone as anything less than 7.20 nmol/L. In recent years some laboratories have lowered this level by shifting the range so that only any level below 7nmol/L is considered below the range.
We know that for those under the age of 40 testosterone tends to be slightly higher in the morning and lower in the evening. Over the age of 40 however there tends to be more variability in this trend. Those who do shift work may see a different pattern as disruptions in circadian rhythm can change when and how your testosterone is produced. This is called the diurnal rhythm. There are also seasonal fluctuations of testosterone where testosterone can be lower during various times of the year. How these factors effect testosterone are either by affecting testicular function, affecting the signal from the brain to the testes or may be idiopathic and of an unknown nature. Whatever the cause, low testosterone can decrease your quality of life.
Testicular issues that can cause low Testosterone
- Varicocele are bundles of veins that can prevent heat loss from the testes which is sub-optimal for the production of sperm and potentially testosterone.
- Blunt trauma causing damage to the testes(testicles)
- Testicular Cancer
- Hydroceole causing inflation.
- Removal of Testicle/testicles
- Undescended Testicles
- Mumps causing orchitis or inflammation of the testes.
- Pituitary Gland issues that can cause low Testosterone
Can traumatic brain injuries (TBI cause low testosterone? Can concussion cause low testosterone? Can testosterone help TBI?
Trauma to the brain TBI or traumatic brain injury can be a cause of low testosterone but also other pituitary functions like thyroid hormone production. Hypopituitary symptoms are seen in up to 76% of patients after TBI and 52% of TBI can go on to develop new hypopituitary issues after 1 year after the injury. This effect can also be seen in accumulative head injuries that chronically develop with persistent mild-moderate trauma. Rugby player, boxers or even day to day head injuries. Testosterone treatment can be used following post traumatic brain injury to aid healing and recovery.
Hypopituitarism following traumatic brain injury: determining factors for diagnosis.Eva Fernandez-Rodriguez1, Ignacio Bernabeu1, Ana Isabel Castro1, Fahrettin Kelestimur2 and Felipe F. Casanueva1,3*1 Endocrinology Division, Complejo Hospitalario Universitario de Santiago de Compostela, SERGAS, Departamento de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, Spain2 Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey3 Centro de Investigación Biomédica en Red de Fisiopatología Obesidad y Nutrición, Instituto Salud Carlos III, Santiago de Compostela, Spain
Other Causes of low testosterone
- Lack of sleep or shift work
- Thyroid issues. Hypothyroidism can sometimes mimic the symptoms of low testosterone and when thyroid hormones are optimised testosterone levels can recover as well as reducing the levels of prolactin.
- Exposure to toxins, chemicals in the air and water and the environment
- Street drug use can diminish testosterone.
- Licroice root overconsumption
- Certain prescription drugs for heartburn may raise prolactin and potentially lower testosterone (ranitidine/omeprazole)
- Overtraining in the gym can lower testosterone levels.
- Marathon running can lower testosterone.
- High blood glucose can lower testosterone.
- Too many refined carbohydrates
- Genetic conditions such as Klinefelter syndrome, Kallman Syndrome, Prader Willy Syndrome, Myotonic dystrophy, haemachromotosis
- Age can affect testosterone levels as leydig cells in the testicles decrease with age
- Alcohol, beer, your favourite IPA
Environmental Causes of Low Testosterone and Endocrine Disrupting Chemicals (EDCs)
When the body is working and optimised it works brilliantly. All hormones are balanced and there is are natural mechanisms to regulate this. The problem is the once natural world we live in is no longer clean or pristine. Our bodies are being assaulted every day with a variety of toxic chemicals. They are in in the air we breathe, and the water we drink, and the plastic substances we touch with our skin. We know these toxins degrade your body’s ability to make optimal testosterone, bind to receptors blocking the effect of testosterone and may even shorten your life. It is impossible to escape a continuous hormone disrupting onslaught when living day to day life. This hormone disruption can only be reduced by avoiding exposure which is likely impossible. The other method is to optimise your hormones and ensure they are balanced.
Types of endocrine disruptors (EDCs)
Each of these can disrupt the production of testosterone:
- Phyto-oestrogens like soy products that we ingest in our food
- XenoEstrogens these are chemical oestrogens
- Oestrogens in the water supplies from birth control medications
Heavy Elemental Metals
- Metalloids like Arsenic
Chemicals found in everyday households:
- CAR EXHAUST FROM DIESEL AND PETROL ENGINES
- Exhaust gases, particularly diesel particulates are known hormone disruptors
Insecticides such as DDT and agricultural pesticides are known disruptors of male androgens.
Water SA vol.41 n.1 Pretoria Jan. 2015http://dx.doi.org/10.4314/wsa.v41i1.16 The potential anti-androgenic effect of agricultural pesticides used in the Western Cape: In vitro investigation of mixture effects
- Fungicides can be anti-androgenic so it’s important to be careful when using or ingesting certain prescription drugs containing various fungicides. Oral fungicides for athletes foot or toe nail fungus can potentially lower your levels of testosterone. Ketoconazole oral tablets are known to lower testosterone after cessation due to its effects on certain enzymes needed for production of testosterone.
BPA, and phthalates, PVC, resins, epoxies, paints, coatings inside tins and metal cans. Coatings on pipes. Found in water bottles, plastic packaging on foods
Herbacides like glypohsate
Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats.Trentacoste SV1, Friedmann AS, Youker RT, Breckenridge CB, Zirkin BR. J Androl. 2001 Jan-Feb;22(1):142-8.
Parabens are oestrogen-like chemicals found in cosmetics, lotions, shampoos, skin products, toothpaste have been shown to reduce testosterone levels in men. Parabens are used in the cosmetic industry as a preservative to reduce the growth of bacteria, fungus, and yeast. The industry has argued that these are essential and the alternative of an infection is worse. Parabens are easily absorbed through the skin and are classified as harmful by the environmental working group in the US.
Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. J Appl Toxicol. 2008 Jul;28(5):561-78. doi: 10.1002/jat.1358.
Flame retardants found in cushions, sofas and mattresses
Required and standardised by manufacturers we are surrounded by these all day every day.
Alcohol from beer, wine and spirits can reduce testosterone levels
Hand Sanitisers may have hormone disruption properties and can lower your testosterone.
Pain Killers like Ibuprofen can lower testosterone. The higher the dose of ibuprofen the larger decrease in testosterone levels.
- Proc Natl Acad Sci U S A. 2018 Jan 8. pii: 201715035. doi: 10.1073/pnas.1715035115.https://doi.org/10.1073/pnas.1715035115 [Epub ahead of print].
- The testosterone effect of ibuprofen 20.04.2012
- Ibuprofen helps immune cells build up muscle tissue 09.08.2010
- Ibuprofen and acetaminophen are anabolic for seventy year olds 24.08.2008
In summary EDCs and other hormone disruptors are everywhere. The issue is they do not cause instant symptoms like vomiting or migraines, they suppress and disrupt hormones causing negative effects over time. If they did cause instant symptoms we believe it would be highly likely that they would have been controlled/removed from our environment more effectively.
Is testosterone safe?
Testosterone and actually hormones in general are not like medications. They are naturally made by the body and repackaged for medical use in a way for you to ingest, inject or apply when your body is unable to make the proper amounts. Testosterone is a natural hormone made by the body. It’s not a foreign substance. Yes it’s entering your body from the outside rather than being made endogenously (within) when on hormone treatment, but it is still the same (bio-identical) hormone that your body sees and utilises
The fact is, testosterone has been licensed by regulatory agencies because it’s been shown to be safe and effective. In order to obtain a licence these drugs must go through rigorous testing at various phases to determine safety and efficacy before being approved. Testosterone has been approved and used for over 75 years. It is not a synthetic molecule and as mentioned is identical to the testosterone that your own body produces. Many men and women have used testosterone for years and years with few if any side effects to treat medical conditions and optimise health. The key is finding the right balance. Too much or too little is not safe and through medical management finding your optimal levels is key.
Testosterone treatments comes in various doses and concentrations Treatment protocols can vary from person to person. Here are some bio-identical types that are/have been used in medicine:
- Oral testosterone called methyl-testosterone was an alpha alkylated testosterone was considered to have some liver toxicity based on dose and duration of use. Oral testosterone is rarely used and really has no place as part of testosterone replacement therapy.
- Injectable testosterone once released in the blood stream and, once enzymatically cleaved from it’s ester, is bio-identical to what the body naturally makes. It is received by the androgen receptor the same way as your own endogenously produced testosterone.
- Testosterone from topical creams or lozenges are also the same testosterone the body makes and stored in a lipoderm medium or a lozenge(troche) with various natural binders or fillers to slow the release into the blood stream.
As mentioned Testosterone has been found to be safe and effective when used correctly but, due to older or flawed studies, there is a perception by some that long term use is not safe. Two areas of concern are Prostate cancer and Heart Disease. The claims of prostate cancer are not backed by any credible evidence. Many studies that pointed in that direction have been reviewed and were seen to be seriouslyflawed or underpowered. There is now more evidence linking low Testosterone to more serious forms of prostate cancer and also heart disease. The general consensus by the medical community is testosterone is safe.
Does TRT cause prostate cancer?
There is no credible evidence to date that testosterone causes prostate cancer. Below are some of the latest studies considering prostate cancer and TRT. The researchers in these studies may not directly advocate TRT for men with diagnosed PCa since this isn’t actually their job (clinicians have to do this) but in every study the researchers clearly imply that TRT is safe and beneficial for those men.
In the presence of a low SHBG level, testosterone enters prostate cancer cells at a faster rate, forcing them to inactivate and efflux testosterone out at a faster rate also. This phenomenon provides extreme stress to prostate cancer cells leading to significant changes in their morphology associated to cancer cell death (growth inhibition/proliferation). This reflects that the testosterone is needed for prostate health.
Does TRT increase risk of heart attack/stroke?
- Low Testosterone shown to be associated with an increased risk of all cause mortality independent of numerous risk factors.
- Serum tetosterone levels were inversely related to mortality due to cardiovascular disease and cancer. This means the lower the Testosterone level the greater the risk.
- Haring, R., et al., “Low serum testosterone levels areassociated with increased risk of mortality in a population-based cohort of men aged 20-79,”European Heart Jour 2010; 31(12):1494-1501.
- Vermeulen, A., “Androgen replacement therapy inthe aging male—a critical evaluation,” Jour ClinEndocrinol Metabol 2001; 86:2380-90.
- Hyde, Z., et al., “Low free testosterone predictsmortality from CVD but not other causes: TheHealth in Men Study,” Jour of Clin Endocriol and Met2012; 97(1):179.
- Guder, G., et al., “Low circulating androgens and mortality risk in heart failure,” Heart 2010; 96:504- 09.
- Jankowska, E., et al., “Anabolic deficiency in menwith chronic heart failure: prevalence anddetrimental impact on survival,” Circulation 2006;114:1829-37.
Will TRT cause my prostate to grow?
J Endocrinol. 2008 Jun;197(3):483-91. doi: 10.1677/JOE-07-0470.Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen.Ho CK1, Nanda J, Chapman KE, Habib FK.
Will TRT cause hair loss?
If hair loss is a worry for you then it is really a choice you have to make and balance the benefits versus the risks of TRT. In our experience clients that had initial worries pre TRT, once they feel the therapeutic benefit of testosterone, fell less worried about this issue once on therapy. There may be options to lessen the affects of hair loss if you are prone to it. The doctor can discuss this with you should you have concerns. These can include other medications. Others may opt for hair transplantation products such as (Regain®)monoxidil.
Will TRT cause my balls/ testes/(testicles) to shrink ?
Will TRT cause my penis to shrink?
Will TRT make my penis bigger?
Shamloul R. Treatment of men complaining of short penis. Urology. 2005 Jun;65(6):1183-5. Baskin LS, et al. The effect of testosterone on androgen receptors and human penile growth. J Urol 1997 Sep;158(3 Pt 2):1113-8
What are the side effects of TRT?
If TRT is managed and administered properly the side effects can easily be avoided and quickly dealt with if they arise. Testosterone use, if not monitored properly or if used in excess, may cause some unwanted side effects. These can be an increase oily skin, fluid retention or oedema, hair loss, hair growth, enlarged breasts, enlarged clitoris (in women), gastrointestinal symptoms, drowsiness, acne, irritability and mood changes. If treatment is provided as an injection, it is possible one may experience soreness or pain and possible infection at the injection site.
If extra fluid in the body occurs as this can cause problems for patients with pre-existing heart, kidney, or liver disease.
There may be sleep disturbances, slight insomnia or an undiagnosed sleep apnea may become apparent/exacerbated. Sleep apnea is more likely to occur with patients who have lung disease or are overweight.
Are there alternatives to TRT
There are alternatives to TRT. Without trying to sound smart, the first option is to doing nothing and waiting to see if things improve. Some attempt to adjust lifestyle factors such as diet and exercise. We often find however that if your body is not producing effective levels of testosterone then doing these things is often ineffective and can make symptoms worse. The second is to speak to the doctor about whether you personally (following blood test etc.) may be suitable for a therapy that may boost your own levels if effective. This can be the use of a SERM or HCG alone to try and improve responsiveness of the testicles. This option sometimes works in younger men but often therapeutically it lacks effectiveness. The third is the possibility of being treated to change your SHBH which is some men can improve symptoms. To discuss a blood test, getting a blood test or whether you may be a candidate for TRT or an alternative contact us and book in a call.
Does TRT cause infertility?
Testosterone is critical for the production of sperm but what is more important is where in the body this testosterone is located. Intratesticular testosterone (the testosterone with in the balls/testes) are present at levels 100x greater than the systemic circulating Testosterone (as measured by a standard blood test). When receiving TRT with exogenous testosterone you provide the body with the testosterone it needs BUT this doesn’t increase intra-testicular testosterone. Actually the contrary happens. The brain detects that there is enough testosterone (as you have provided this via injection or cream etc.) so it switches of the signal (LH and FSH) from the brain that tells the testicles to produce testosterone and sperm. This causes a drop in intra-testicular testosterone and sperm production which can reduce fertility in some men, despite having good levels of systemic circulating testosterone.
HCG can be used alongside TRT to restore the signal from the brain, increase intratesticular testosterone and restore/maintain sperm count. This is why our Doctors at Balance my hormones provide HCG alongside a balanced TRT protocol to maintain fertility whilst optimising testosterone and other hormones.
So testosterone treatment on its own or with anastrozole may be even easier to recover from should fertility be desired and HCG is not available or wanted when starting TRT.
Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ, Wang C. Hormonal Male Contraception Summit Group. Rate, extent, and modifiers of spermato- genic recovery after hormonal male contraception: an integrated analysis. Lancet 2006;367:1412–20.
Can I maintain fertility on TRT
One way to maintain fertility whilst on TRT is to keep a very high level of testosterone within the testes. This is achieved by ensuring the testes produce testosterone locally. The most common and cost effective method is to add HCG to a TRT protocol and ensure estradiol is managed. HCG mimics the actions of gonadotropins LH and to a lesser degree FSH to maintain fertility. Many of our clients choose Balanced TRT with HCG and oestrogen control so they can essentially have both the benefits of exogenous Testosterone whilst keeping the signal to the testes present.
Can I take HCG on it’s own
Some men may choose for various reasons not to start full TRT with exogenous testosterone. For some men who have highly efficient testes, adding a stronger signal than the brain can provide, via HCG or HCG combined with HMG, can help provide enough testosterone without adding and outside exogenous source from injections or creams. We have had a few of our patients opt for this. Exogenous HCG causes milder suppression of the HPTA axis than exogenous Testosterone does. In one paper in 1978 it actually showed an improvement in LH from the pituitary whilst on exogenous HCG. Whilst on HCG the signal the testes receives is amplified and you can have an increase in testosterone levels if the testicles respond. There are cases where the testes are inefficient at producing testosterone despite the signal reaching it. This is called primary hypogonadism and in these cases HCG will not help you make adequate amounts of testosterone and you may still be rendered hypogonadal. In these cases the doctor would reccomend exogenous Testosterone, with out HCG.
HOW CAN I FIND OUT IF I AM FERTILE
And the low testosterone epidemic we’re currently facing has huge ramifications for fertility.Although you think we exaggerate when we say low testosterone is a problem of global proportions.
Indeed, a study was undertaken on male sperm count in North America, Australia New Zealand and Europe between 1973 and 2011 by the Hebrew University of Jerusalem.
And the results were SCARY.
The study analyzed the data of 42,935 men and in this period it states male sperm count declined by 50-60%.
The researchers even concluded that by 2040, the majority of men will be infertile.
There are many possible reasons for this. In day to day like we are exposed to a barrage of toxins, be it substances that act like oestrogen on out body in cosmetics and personal hygiene products, diesel particulates, to antidepressant and contraceptive pills that are found in our water supplies worldwide. Pesticides are hormone disruptors and found on the majority of our foods. Plastics house most of the things we eat and drink and are known to be endocrine disruptors.
If having doubts about fertility Balance my hormones offer a male fertility check for just £250 that allows full analysis of sperm and hormones. This will allow you to see the current state of the hormones in your body that could be negatively affected and if you have any fertility issues.
If you do discover that you could improve your fertility, you can take action. Book a call with us and see what the next steps would be.
DO I HAVE TO STOP TAKING TESTOSTERONE IF I WANT TO HAVE A BABY (can I have a baby whilst on TRT)?
What you can do is also supplement with exogenous HCG alongside TRT. HCG is important because it replaces the LH and FSH signalling and allows stimulation of testosterone production at the testes where it’s needed for fertility.
If following antiquated advice to stop TRT for the sake of fertility it will cause a man return to his previous low testosterone levels causing all of the negative symptoms associated with it.
When common low T symptoms are erectile dysfunction anxiety and lack of libido it becomes obvious that this can be counterproductive when trying to conceive. There are better ways to maintain your fertility or augment your fertility whilst being on TRT.
Recent studies and our doctor’s clinical experience has shown that when HCG is added to testosterone treatment at 500IU two to three times per week, intra-testicular levels remain high enough to regain or maintain sperm count needed for fertility. Even if you don’t start with HCG with your TRT and then decide to add it later, you can, providing you had testicular function that allowed fertility prior to TRT regain this once more.
IF stopping TRT
The alternative to HCG as an adjunct to TRT is to stop taking exogenous testosterone and wait 3 to 18 months for fertility to gradually return. If deciding to abruptly stop TRT, you can accelerate recovery by including a SERM (selective oestrogen receptor modulator) called clomiphene along with HCG as you prescribed fertility treatment.
Clomiphene and HCG are used off licence in men for inducing fertility. The clomiphene helps stop the negative feedback that results from too much testosterone. It inhibits the brain or pituitary from sensing elevations of oestrogen. When the pituitary senses low oestrogen it begins to increase the amount of signalling of LH and FSH needed to instruct the testes to make more intratesticular testosterone and sperm.
We have seen multiple cases where men have swapped from their TRT with HCG protocol and replaced it with the SERM/HCG protocol with negative consequences. They quickly felt fatigued, had low libido, and often low in mood. Shortly after they returned to the TRT/HCG protocol they reported success in conceiving. This demonstrates the power of TRT with HCG for conception.
Of course it is a personal preference what a man decides to do for regaining or maintaining fertility. The least disruption to your balanced state is ideal for most men. Unfortunately for some, their female partners may have some misconceptions about testosterone and force their male partners to stop TRT testosterone completely before trying to conceive.There is no medical evidence to support this but ultimately it is common for men feel compelled by their female partners to comply with their wishes despite medical advice contradicting their viewsaqa. In the end this causes unnecessary suffering for the male partner. We have unfortunately seen this.
Does TRT or HRT have an antiageing effect?
We know from studies that the telomeres through the actions of hormones may have an anti-ageing effect. One study recently published, shows women on long term HRT had the longest telomeres. It is thought that longer telomeres are associated with longer lifespans and greater potential longevity. Shorter telomeres are related to ageing and disease.
Testosterone has been shown to increase the production of an enzyme called telomerase. This enzyme keeps the telemeres from shortening and thereby having an anti ageing effect.
- Danielle M. Townsley, Bogdan Dumitriu, Delong Liu, Angélique Biancotto, Barbara Weinstein, Christina Chen, Nathan Hardy, Andrew D. Mihalek, Shilpa Lingala, Yun Ju Kim, Jianhua Yao, Elizabeth Jones, Bernadette R. Gochuico, Theo Heller, Colin O. Wu, Rodrigo T. Calado, Phillip Scheinberg, Neal S. Young. Danazol Treatment for Telomere Diseases. New England Journal of Medicine, 2016; 374https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968696/(20): 1922 DOI: 10.1056/NEJMoa1515319
Can TRT help grow my facial hair?
Does TRT help build muscle?
Does TRT help with fatigue?
Fatigue is one of the symptoms related to low testosterone. TRT can help reduce or improve fatigue related to low Testosterone. There are cases of non Testosterone related fatigue and it may be due to other hormone deficiencies like thyroid which need to be addressed separately. Many of our clients after starting TRT report being able to get through their day without coming home from work and crashing on the sofa. Sometimes thyroid hormones are needed in addition to testosterone treatment if their is an underlying or masked hypothyroidism.
Does TRT cause man boobs (gyno)(gynocomastia)(bitch tits)?
In the male body, testosterone converts into estrogen through a process known as aromatization.
And when testosterone rises, so does estrogen. But if there’s too much estrogen in the body, this can cause nasty side effects, including:
- Gynaecomastia (Man boobs)
- Swelling / Puffiness
- Poor erection quality
- Moodiness and irritability
- Water retention
- Poor libido
- Oestrogenic body fat deposition
This is one of many factors that needs to be monitored closely on TRT. Levels will be checked before and during TRT regularly to ensure symptoms don’t arise from too high (or too low!) Oestrogen. This way they can often be prevented and if they do occur then quickly and effectively treated.
These side effects can usually be managed quite easily if they come up. Balance My Hormones can facilitate sensitive estradiol tests for men to give a true indication of your estradiol level.
Can trt improve interest in sex (libido)?
What blood tests are needed for TRT in the UK
The world of testosterone replacement therapy is often difficult to navigate. It is filled with misinformatio and bro-science on forums. You may have many of the symptoms of low testosterone, but confirmation is needed via blood tests. When undertaking this next step you must be tested for the right things. Testing for testosterone alone will not tell the full story the reason being your body is complex and hormones don’t work in isolation.
Going to your NHS doctor for a blood test is the first port of call for most men. The problem is, they often lack specialist knowledge in hormones – especially testosterone.
Often they dismiss your symptoms out of hand – because you ‘don’t need to worry’ about testosterone and if you do manage to get a test through the NHS, they usually don’t test for the right things anyway.
So what’s the alternative?
We offer a comprehensive hormone panel that can be done from the comfort of your own home at competitive price.
We recommend this hormone panel for individuals that want to find out what’s going on, and who are perhaps unsure if TRT would be for them.
The hormone Pre-TRT panel tests for:
- Serum testosterone
- Free testosterone(calculated) as assays tend to be unreliable from lab to lab
- Sex Hormone Binding Globulin
- LH-Luteinising Hormone
- FSH-Follicle Stimulation Hormone
Hormones are the foundation of your health as a man, and testosterone is central to that. Creating a picture of the hormonal system with your body and how effectively it is working
is the first step on the road to getting symptomatic relief
COMPREHENSIVE TEST FOR CONFIRMATION AND TREATMENT FOR TESTOSTERONE DEFICIENCY
A second test is also required to ensure the safety of starting TRT and to create a clearer picture of the consistency of levels of hormones in your blood.
The tests required give you a picture of how the rest of your body is working. The test will check things like Haemotology including red and white blood cells, Biochemistry, Liver function, Kidney function tests, Lipid levels, PSA, Testosterone, SHGB, Oestradiol, Prolactin and a Full comprehensive thyroid panel.
What are HIGH SENSITIVITY OESTRADIOL BLOOD TESTS or LC-MS or Liquid C Estradiol Tests?
Standard testing for oestradiol uses a technique that may provide a slightly different result than the LC-MS test used in the US. The standard oestrogen assay via RIA(Radio Immuno Assay) method whilst the standard in the UK is falling out of favour with TRT providers in the United States and elsewhere.
The standard RIA Oestradiol test is a very precise tool however it may lack accuracy to the gold standard LC-MS. In other words every time we measure your oestradiol with RIA test then there may be slight fluctuations but you can still create a useful picture of where your Oestrogen sits and when comparing to symptoms can guide adjustments in therapy. There are times when the levels are borderline or whether symptoms demand it that would warrant the use of the high sensitivity Oestradiol test using LC-MS method.
Balance My Hormones can arrange to have these blood tests done through a specialty lab. Often people will use the same blood sample to test the RIA tests and LC-MS test for comparison.
How much does TRT cost in the uk?
TRT can cost anywhere from your time and excess prescription fee from the NHS or thousands of pounds at private insurance based clinics.
Balance My Hormones offers sustainable treatment packages that focus on support through the process. Our Doctors and experienced medical facilitator team, that act as patient to patient advocates, allow receiving private UK and EU TRT an effective and efficient process.
Contact the team today to discuss your potential costs
How do I get trt in the UK with the NHS?
Because of its centralised structure, it is usually shacked and inflexible when trying to treat patients for low testosterone.The Process
First you should to visit your GP to explain your symptoms you’re experiencing. Depending how sympathetic they are, they will send you off for a testosterone blood test.
They will normally send you for two lab tests to confirm a diagnosis of low testosterone. Tests are typically done before 9am, which in theory is when testosterone is at its highest.
Once the GP gets the lab results back confirming you have low testosterone, they will refer you to an endocrinologist.
The endocrinologist upon examination and review of your labs that must fall with in a narrow unforgiving reference range of under 6nmol/L in some cases may then reluctantly prescribe you TRT treatment usually in the form of a 4ml slow release testosterone injection once every 4 months which leaves you in a hypogonadal state for a third of the time, or. topical that does not provide enough testosterone.
Generally speaking, the NHS standardised model of care works well for many medical conditions. Patients visit their doctor with symptoms and have tests to validate the symptoms, they are then treated accordingly.
However, the NHS has serious flaws when it comes to treating a condition as nuanced as low testosterone. The need for an underfunded service to always be comparing cost to efficacy limits this provision.
Firstly, most doctors, let alone GPs are not well informed on testosterone replacement therapy. So you might end up being treated for depression with medication instead of a testosterone deficiency.
Although you may have open-minded GP who is willing send you for further tests, if your blood tests show your total testosterone within the so-called ‘normal’ range, then in most cases you’re out of luck. This is because
doctors are trained to treat for testosterone deficiency only when patients’ testosterone levels are outside the normal reference range regardless of their symptoms.
Even if they want to help, their hands are tied.
If you do manage to get a referral to an endocrinologist, you may have to wait several months for an appointment. Furthermore, once you do get to see an endocrinologists, there is no guarantee you will get the right type of treatment.
The method of treatment tends to vary significantly between specialists. Some may prescribe testosterone gels to their patients, whereas others may ask you to inject every 2 weeks (help!) or a massive injection every 12. Every one of these options either leaves you with periods of high then low testosterone or not enough from the therapy at all. The NHS will not monitor oestradiol levels, and rarely will they monitor prolactin or free testosterone levels. We have even seen men end up with lower testosterone levels ON therapy than before they started!
This entire process could take many months.
For those that do receive effective testosterone treatment on the NHS are very fortunate. But there are many that fall foul of the standard care model and end up frustrated because they cannot get treatment or get a treatment that causes them to feel worse than before.
There are no doubt GPs and endocrinologists in the NHS who do an excellent job. But in order to qualify for testosterone replacement therapy on the NHS, patients have to jump through countless hoops as described above. It can be a painful time-consuming process where you will either feel like you have been fobbed off or if you are extremely lucky and find a doctor that knows how to provide TRT effectively then it can feel like hitting the lottery.
At Balance My Hormones you won’t have to wait months to see a specialist. You can get the process started with an open-minded and experienced hormone replacement therapy doctor.
You can get approval for treatment in as little as 48 hours if you have all the appropriate blood tests and forms complete. If you don’t get a diagnosis for TRT then you don’t pay the doctor’s fee. And we aim to treat our patients as individuals – not just as a lab number.
What’s more, you don’t always have to go out and physically visit your doctor. You can have a remote consultation in the comfort of your own home that is flexible and fluid.
The service is concierge so you have the doctor’s email address if you have questions. Also staff at Balance My Hormones are always on hand to assist in other aspects related to your care. So if you think you’re suffering from the symptoms of low testosterone, get in contact with us today.
How do I get TRT on the NHS? Will my GP prescribe TRT in the uk?
In our experience many of our clients come to us following a search for an open minded GP that had then referred then to a consultant endocrinologist. This usually takes 6-8 months. After having seen the consultant and having further tests which may show levels above the NHS threshold for treatment they are often simply fobbed off and told there is nothing wrong and treatment is withheld. This not only is disappointing for the client but it exposes them to s further 6-8 months of low Testosterone symptoms. We have heard from clients who had gone to the NHS and were refused treatment despite them having total levels of testosterone as low as 6 nmol/L.
If attempting the NHS route you would have to find an open minded GP that is willing to treat you. For this you would need two blood tests that show your levels under the NHS threshold for treatment. Even if this happens your treatment options will likely be a 4ml large injection every 12 weeks (NEBIDO) or a low strength Gel (ANDROGEL or similar alternative). Neither of these options show great efficacy in practice, they cause fluctuations in levels or don’t provide enough Testosterone at all. In are cases sustanon has been used but only dosing every 2-4 weeks. So even if you get one of these options the NHS will not monitor Oestradiol (oestrogen) levels and rarely will they monitor prolactin or free testosterone levels.
How to get private TRT in the UK and Europe?
Balance My Hormones is a unique service which combines an online platform with full support level of service for clients looking for TRT in the UK and Europe.
Balance My Hormones is under the supervision of medical doctors, and pharmacists and acts on their behalf to support the connection between the patient our clients and the private independent doctors, pharmacies and laboratories. Balance My Hormones brokers and provides adult safeguarding and patient to patient advocacy support whilst creating an open environment to discuss personal experiences and the collective experience of others on TRT so as one who is new to TRT you don’t have to feel alone.
Many times with traditional doctor practice set ups there just is not the support capacity. The balance my hormones team is there to provide this support and coordination and reassurance.
Our clients are at all times monitored by the doctor and the use of our medical facilitators assists our doctors in completing this task. Our medical facilitators are either trained in hormone therapy and have previous health care experience with the NHS, or in private healthcare and they may have been patients on hormone therapy as well. Having this background can offer a unique insight that you will not find anywhere else in the UK and Europe. TRT Medical Facilitators will help you with the patient intake and help get you efficiently to blood testing, to the doctor, and then the pharmacy.
All of the logistical parts are handled by our staff so you don’t have to collect at the pharmacy as all your treatment plan medications are posted directly to you. You can get the process of private TRT in the UK and Europe started by contacting us and filling out a confidential online form.
Will Brexit affect getting TRT in the UK?
For our European clients we have an EU partner pharmacy, and doctor partners in Europe.
There is a good chance TRT will be available but preparations for the event of a no deal Brexit is the most prudent course of action. We can work with you, the doctor and pharmacy with logistics of future issues.
Do I have to be on TRT for life?
This is a common question/concern. In this situation the question that must be asked is what the alternative is. The options being to continue as you are with sub-optimal or dangerously low levels of testosterone for life with all the symptoms it causes or would you like medical treatment to optimise these levels and bring symptomatic relief.
There are Testosterone boosting protocols other than TRT but stopping these therapies does not often sustain the increase in levels achieved. You may be worried about the perceived dependence of having to take a hormone for life to allow symptomatic relief and bring about health benefits but if it allows all these things it must be considered against the alternative.
Another common question is if your body can start making testosterone again on its own after dicontinuing treatment. In nearly all cases and from the literature the answer is yes. It takes time with the median being 3.5 months but we have seen from experience that within a few weeks those that stop can recover to at least the baseline from where they started. It must be noted that the baseline was insufficient and was causing symptoms however.
A common and antiquated opinion is that cycling testosterone is beneficial but there is no benefit for going on and off testosterone. It just causes periods of hormonal deprivation, disrupts homeostasis and caused Hypogonadal symptoms to come back.
What happens if I stop TRT? What happens if I need to come off TRT?
If testosterone replacement therapy relieves your symptoms of low testosterone, then often ceasing will cause your symptoms to recur. It is for this reason that TRT is usually a lifelong commitment. This may sound daunting, but once you feel the symptomatic relief and benefits of testosterone therapy, stopping treatment often becomes less of a concern.
Should you need to stop TRT there are ways to assist the body in producing its own levels of testosterone faster than just stopping TRT alone. In some studies the median time for recovery of sperm is around 3.5 months. Testosterone production can return in some individuals in as little as 3-6 weeks. Factors affecting how quickly your testosterone will return depends on the original strength or signal from the pituitary gland (Leutinising Hormone and Follicle Stimulating Hormone), and how sensitive or efficient your Leydig cells (testosterone producing factories) located in your balls(testes) are.
In our experience this can occur quite quickly. It must be noted that if you are starting from a low baseline before beginning TRT restoration back to this lower level is likely all you will achieve.
What if I can no longer afford treatment?
You are under obligation to continue treatment. It is a private service and therefore a personal choice. However, in the grand scheme of things our treatment packages are affordable and sustainable and priced around your budget and medical advice from the doctor. Please contact us and we can work with you and the doctor to find a package that is right for you.
What is the best type of TRT in the UK and Europe?
The best type of TRT depends on what is best for you the client as determined by symptoms and blood testing and discussions with the medical facilitators and doctors.
Some prefer injections, some prefer topical formulations. The doctor can determine administration dose and frequency depending on blood tests, age, medical history etc. It is highly individualistic the type of treatment that may be needed and a careful process must be undertaken to find what is best for you.
Injectable Testosterone Preparations
- Sustanon®(Aspen), testosterone propionate 30 mg, testosterone phenylpropionate 60 mg, testosterone isocaproate 60 mg, and testosterone decanoate 100 mg/mL. If you are allergic to peanuts or benzyl alcohol then this preparation would not be for you.
- Testosterone Enantate or Testosterone enanthate(Non-proprietary) , testosterone enantate 250 mg/mL dosed 250mg every 10-14 days- this is a more expensive option as there are limited manufactures in the UK. If you are allergic to castor oil, or benzyl benzoate then this would not be for you.
- Testosterone Propionate 100mg/2ml 2-mL amp Short Acting Testosterone ester dosed 2-3 times weekly
Topical Testosterone Options
Bespoke bio-dentical topical testosterone for HRT and TRT
- Bespoke testosterone lozenges made in the right formulation for women and can be combined with bio-identical oestrogen’s and progesterone.
- Bespoke high concentration cream prepared by a compounding pharmacy
- Branded Testosterone Creams and Gels (often least effective)
HCG-Human Chorionic Gonadotrophin – used to help treat delayed puberty, undescended testes or oligospermia (low sperm count). This treatment can be used as monotherapy or as an adjunct with exogenous testosterone to maintain testicular size and fertility. Your doctor will discuss with you an individual treatment plan.
HMG-Human Menopausal Gonadotrophin- used as an adjunct for fertility and can be used along side TRT. This preparation
Are higher doses of testosterone Dangerous?
Our doctors are looking to find the optimal dose of testosterone for you. Some men feel better with higher doses than others. The lowest effective dose is always preferred but this can vary between individuals. Factors such as age, metabolism, location of injection site, SHGB levels, can affect the ideal dose. Frequency and timing of dosing is often more important. Normal is a relative term. There is some variability between individuals, as some men may have had higher than average levels as teens and young adults only to have a lower levels as middle age men. These lower testosterone levels could still sit in the middle of the range but these men would have suffered a vast drop in the levels that the body is used to.
What would be a high dose of testosterone and is it dangerous?
Traditionally testosterone is prescribed at a dose of 250mg every 2-4 weeks. We know this treatment regime leaves a man with large peaks and low troughs. This roller coaster effect is not optimal, cause unwanted symptoms and should be avoided.
A more current dose would be 100-125mg of injectable testosterone every 5-7 days.
What would the effect of an even higher doses be on fertility and and safety?
A 1990 study looked at the safety of various doses in the range of 25,50, 100, or 300mg of injectable testosterone enanthate injected weekly. The conculusion was with exception of body acne, mild elevation of haemtocrit, weight gain no significant adverse health effects of chronic high dosage were found. In fact the 300mg dose did not reliably suppress the production of sperm. This demonstrated that even a 300mg weekly dose of testosterone would likely be ineffective as a form of male birth control. Whilst we are not advocating taking more than you need, it’s important to understand that Testosterone treatment doses can vary between individuals and when monitored by a doctor can be safe even at slightly higher doses.
J Clin Endocrinol Metab. 1990 Jan;70(1):282-7.Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production.Matsumoto AM1.
Should Testosterone Replacement Therapy be offered on the NHS ?
How do I administer TRT and do I have to inject on TRT?
There are several ways to administer Testosterone Replacement Therapy. However, the most commonly prescribed methods are testosterone injections testosterone gels and testosterone creams.
Before undergoing TRT, it’s important to understand the main distinction between these methods. You should also understand the pros and cons of each, so you can make an informed decision on your treatment.
Transdermal Testosterone Gels and Creams
The reason they’re so popular is because they’re simple to use. They are usually applied to the skin in the morning and the evening before bed for best results. . Typical areas of application include; the shoulders, upper arms and scrotum. Gels and creams tend to come in various concentrations.PROS
- They are easy to use and apply
- Absorption through the skin cause testosterone levels to fluctuate, thereby closely mimicking the body’s own production
- Absorption through the skin may be inefficient, due to sweat, food consumption, etc
- May produce oily skin due to elevation of DHT and cause estrogenic side effects
- Unable to wash, swim or engage in vigorous exercise for hours after application
- Possible transfer risk to others
Intramuscular testosterone Injections
Testosterone injections are another form of commonly prescribed TRT treatment. It has been considered the standard of care. Treatment efficacy is dependant on the type testosterone preparation used, e.g. Sustanon, Enanthate, Propionate and administration frequency.
Testosterone can be injected one of two ways; subcutaneously (subQ) – i.e. through fat, or intramuscularly (IM). Doctors prescribe testosterone injections because of their predictability and titratable nature. This allows stability of blood testosterone levels.
- Injections allow testosterone to effectively reach the bloodstream, minimising loss of T through absorption that may happen with topical testosterone preparations.
- Helps to maintain stable levels of testosterone, avoiding so-called ‘peaks and valleys’ and is easily adjusted
- Doesn’t prohibit you from engaging in other activities
- Requires training to practice correct injection technique
- Takes practice before being confident filling testosterone into a syringe and self-injecting
- Using needles is daunting for some, and they must be disposed of properly
There is no right or wrong choice. Both injections and some topical formulations can be effective methods of treatment for low testosterone. The question is, which one is right for you? Ultimately it depends on your individual circumstances.
Using a topical formulation would be the easiest route for administering testosterone replacement therapy if you are not able to comfortably inject. They’re easy to apply with minimal hassle.
But if you are someone who leads an active lifestyle then they may not be for you. Sweating interferes with the absorption of the testosterone if you’ve recently applied it, requiring reapplication. Similarly, the topical formulation such as a cream or gel can be transferred to another person if contact with skin where it was applied. This is often why scrotal application can be beneficial.
Remember, any decision on treatment should always be taken under the supervision of a qualified doctor. If you want to book an appointment with a doctor to discuss testosterone treatment options, then get in contact with us.
Are there famous people or celebrities on TRT and hormone therapy?
Of course there are famous people and celebrities on TRT just as there are millions of non-celebrities on TRT. We are all human at the end of the day. We know that optimising Testosterone and other hormones have anti-aging effects. TRT or HRT is a medical treatment and not just used for cosmetic purposes as some may believe.
To many, famous people are role models. Testosterone replacement therapy should not be a luxury. Often people are of the opinion that HRT and TRT are available to celebrities. You do not see other medical treatments like insulin or antibiotics being reserved only for famous people. Every man or woman should have the opportunity to have access TRT or HRT regardless. Celebrities receiving Testosterone Replacement Therapy and HRT are raising the awareness of the need to optimise hormones in ageing men and women.
Conversely celebrities disclosing to the public the use of TRT via the media often causes TRT and HRT thought of as merely for cosmetic reasons rather than something that is essential for health.
Here are some celebritiess that have reported as using TRT:
There is practically an urban legend around Sylvester Stallone arriving in Australia in the early noughties to make a film with large doses of human growth hormone only to be confiscated by the customs authorities.
Antonia Saboto Jr the Come Dance with me Star has had an article written about his use of TRT in the forms of pellets inserted under the skin for his TRT. (Pellets may be a good option for some as they can be inserted every 4 – 6 months but this is less popular as there are often more optimal methods of administering TRT)
Ageing men who want to preserve their youth and longevity are looking to replace their testosterone. The baby boom generation are well known for wanting to age gracefully. Prescriptions of testosterone have doubled since 2006 in the US and requests for testosterone blood tests in the US have increased 137% from 2001 and a similar pattern has been seen in the UK.
Joe Rogan discusses his long term use of testosterone replacement therapy on his podcasts and invites others to share their experiences.
Dorian Yates on TRT- former bodybuilder discussed the benefits of optimal testosterone on health for ageing men.
Balance My Hormones takes patient confidentiality seriously and would never divulge any of our clients details celebrities or not. We have helped many men and women from all different careers and walks of life optimise their hormones and health including: doctors, people in entertainment industry, law enforcement members of the military, executives in business and finance. We do not facilitate professional athletes and have a strict anti-doping policy. It really shouldn’t matter whether or not those more publicly visible are using testosterone if it is needed.
Is TRT the same as anabolic steroids?
Testosterone Replacement Therapy is medically restoration and optimisation of testosterone levels using bio-identical testosterone. The treatment aims to reduce the symptoms of low testosterone and to actually feel the absolute best you can. Options include testosterone injections, testosterone creams or testosterone gels, testosterone lozenges or testosterone pellets. These all contain testosterone and need to be utilised in a way that releases optimal amounts of the hormone in a steady and stable manner. Anabolic Steroids were developed for medical use. They were made by altering the structure of hormones, like testosterone to make them more anabolic and often less androgenic. Alongside testosterone these were used to maintain muscle mass and function in cases of people suffering with disease or episodes of illness or trauma that caused muscle wasting.
The testosterone molecule is the base model that Anabolic Steroids are built from.
As mentioned anabolic steroids are modified synthetic versions of testosterone that have similar structures but are not quite the same. They differ to testosterone in anabolic and androgenic effects. Androgen hormones bind to the androgen receptor. This begins a cascade of effects on the body. Like testosterone, anabolic steroids can fit into androgen receptor and activate it like testosterone can. Once bound the exert differing effects. Anabolic steroids vary in level of activity at the androgen receptor. Their effects are androgenic and anabolic at different ratios.Alongside this, Anabolic Steroids have different metabolites that also can cause other effects in the body.
Some anabolic steroids improve nitrogen retention rapidly, leading to enhanced lean body mass. This can be at a greater degree than natural testosterone. They do not exert the same effects on the body that testosterone does so cannot be a substitute. They also will suppress the body’s natural testosterone levels causing impotence.
Anabolic steroids are used medically and in some cases as an adjunct to TRT. Nelson Vergel. mentions this in his book- Built to Survive where Anabolic Steroids were used with testosterone to maintain muscle mass in wasting diseases like HIV.
The base of TRT treatment is testosterone and long term use of only anabolic steroids may not always be ideal and is normally not recognised as the standard of care for TRT as a monotherapy.
Steroids. 2009 Feb;74(2):172-97. doi: 10.1016/j.steroids.2008.10.016. Epub 2008 Nov 5.Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities. Applied modifications in the steroidal structure.Fragkaki AG1, Angelis YS, Koupparis M, Tsantili-Kakoulidou A, Kokotos G, Georgakopoulos C. PMID: 19028512 DOI: 10.1016/j.steroids.2008.10.016
How is low T (testosterone) diagnosed?
Low testosterone is diagnosed by looking at symptoms and confirming with blood tests. The doctor will need to at least 2 blood tests within the last 3 months. It’s important to have testosterone measured at 2 different time points. In addition to testosterone, the doctors will look at other values including SHGB, Free Testosterone, Oestradiol, and Prolactin.
A second test looking at a repeat of the first test plus Haemotology, Liver function tests, biochemistry, thyroid panel, and PSA are also needed.
How can I balance my hormones?
Hormones that can be balanced:
- THYROID HORMONES
Hormone balancing really is the art and science of making sure all the hormones are optimised for the individual using blood tests and symptoms as a guide. Sometimes managing one hormone may lead to imbalances in other hormones.
Optimal level for men is 25-35nmol/L
Optimal level for a woman is 0.6-1.5nmol/L
Testosterone can fluctuate whilst on TRT no matter which treatment modality you choose. If you are using topical testosterone then the level will be highest at the peak and reduce near the 12-24 hour mark or the trough. Injectable testosterone like Sustanon or Testosterone enanthate will peak in 12-24 hours and gradually fall to hypogonadal levels in 14 days.
The method most often quoted in research papers is the calculated free testosterone and it’s considered the gold standard over unreliable direct free testosterone assays. Free Testosterone can be low despite having adequate amounts of total testosterone. It’s important to gather the data needed to calculate this test which includes the SHGB and albumin for the most accurate calculation for Free Testosterone. Many men suffer needlessly who are truly testosterone deficient because their GP will only order a total testosterone and not the constituent parts needed for calculated Free Testosterone.
Optimal oestradiol level in a man 100pmol/l -120pmol/L (up to 160 pmol if non symptomatic and tested with standard blood test for E2 in the UK. We have seen the standard test return at 155pmol/L and the same sample taken the same day analysed with LC-MS at 100pmol/L.
When testosterone is added to a male there can be elevations in oestradiol. If the oestradiol to testosterone ratio becomes too high then it is out of balance. Reducing the testosterone dose and frequency or adding a low dose of an aromatase inhibitor may help balance this.
For a women going through menopause or peri-menopause having the right type of bio-identical oestrogen in the right form is essential.
Optimal Prolactin levelin a man 86 -290 mIU/L
Levels of prolactin can fluctuate. Many stressors of daily life can cause an elevation in this level after a blood test. It’s best to do this test fasted in the morning. Refraining from exercise the night before and morning of the blood test as well as refraining from ejaculaiton will provide a more realistic picture of the state of your prolactin level. Hormones in the body are like a web and and are interconnected. Hypothyroidism for example, or too much oestrogen, can cause Prolactin to rise. We can sometimes see an elevation of prolactin shortly after starting TRT. This usually subsides back to a normal level. It can sometimes require management using a dopamine agonist to optimise the level and improve symptoms if after several blood tests over 3-6 months show continued elevation.
When prolactin is elevated the symptoms can be awful for men a including impotence, fatigue and lack of libido. Common medications such as Anti-depressants and anti-acid medications like omeprazole can cause levels of prolactin to be higher.
Thyroid hormones may also need to be balanced. Elevated TSH with normal levels of Free T3 and Free T4 may indicated subclinical hypothyroidism. In some cases symptoms of hypothroidism can be shared with/similar to those of low testosterone. The doctor will normally start by managing one hormone at a time until they are all in balance. Low thyroid (Hypothyroid) states can also elevate prolactin levels.
Progesterone competes with estradiol in men. Progesterone can sometimes elevate or decrease whilst a man is on exogenous testosterone hormone treatment. Having progesterone levels in balance in essential for mental health. Progesterone supplementation can be prescribed or supplementing with HCG may help to back fill the pathways for your body to naturally produce this. Lack of progesterone can lead to increased anxiety for some as progesterone has a calming effect on the body and can help reduce stress.
For women progesterone is part of the menstrual cyle. When menopause hits, progesterone levels often drop. Progesterone can be added to HRT for women to create balanced HRT.
Pregnenolone is an adrenal hormone that is made from cholesterol the starting point for steroid hormone synthesis (some times referred to as “the mother hormone”. Low pregnenolone can cause issues with cognition, mood and energy. Taking HCG or pregnenolone may help replenish levels of this hormone. A simple test can determine your levels. Pregnenlone can also help women experiencing menopause.
SOMATOMEDIN C/ IGF1
(IGF1) Insulin like Growth factor 1 is a hormone that is stimulated by human growth hormone release. It’s a reliable method of measuring output of growth hormone. IGF or somatomedin can also be replaced directly with a synthetic recombinant version or exogenous HGH somatropin can be used to raise the levels of IGF1.
Exogenous human grown hormone or somatropin can help bring up these levels. Ideally small pulsatile doses at once or twice per day of 1-4IU can help optimise IGF1. Human Growth hormone has it’s own targets and benefits besides raising IGF1. Fat loss and lean muscle mass as well as shifting metabolism to bring fat instead of carbohydrates are some of the benefits of these hormones. Growth hormone can also enhance the effects of the androgen receptor as well so it works synergistically with testosterone.
The adrenal glands which sit on top of your kidneys produce a hormone called cortisol and is known as a “stress hormone”. You need this hormone in the body to help balance blood sugar, blood pressure, energy levels and to reduce inflammation. Like all hormones you want levels to be in the optimal zone. The test should be measured in the morning with a serum blood test and throughout the day with a saliva test. You want higher levels in the morning and decreasing throughout the day. Levels that are too high or too low are not ideal and may indicate Cushing’s or Addison’s Disease respectively.
Optimal levels of Cortisol in the morning 150-200ng/ml
How can I stop high oestrogen(estrogen) on TRT
Oestrogen is very important for healthy bones, libido, and general health so you must have enough. Too much oestrogen from excessive conversion of testosterone is not ideal and does need to be managed either through dose reduction/adjustment or the use of an aromatase inhibitor.
Elevated oestrogen may cause man gynocomastia(man boobs), irritability, elevated blood pressure, and hot flushes even when on TRT.
Often reducing dose doesn’t always work. If you carry excess adipose tissue or fat especially around the abdomen then lowering Testosterone may not be enough to lower the oestrogen production.
We have seen cases of men pre-TRT where the testosterone was low but the oestradiol was high. Lowering the testosterone in this case would be counterproductive. Careful use of an aromatase inhibitor may be essential for some men and our doctors are open to this approach when appropriate. It makes no sense to replace a natural low level of testosterone with an artificial low level of testosterone just to manage oestradiol.
As long as oestradiol does not drop too low for too long then there is little risk of bone loss related issues. The optimal level of Oestradiol from RIA (Radio Immuno Assay) analysed blood samples is around 100 to 155 pmol/L.
Standard blood tests in the UK usually overestimate the amount of oestradiol in the blood. This is why our doctors are comfortable having your levels in this range. If your doctor vociferously refuses to consider the use of low dose aromatase inhibitors then you may want to seek a new doctor.
High Sensitivity Oestradiol testing is available in the UK through balance my hormones and helps in determining the need for an Aromatase or whether any action is needed at all when the levels of oestrogen are borderline. Our doctors are experienced in managing oestrogen and are open to the appropriate use of Aromatase inhibitors that is backed up by evidence.
How is HCG used with TRT?
HCG can be used in many ways to enhance TRT. HCG is important as it mimics the signal going to your testes, from the pituitary, that stimulates Testosterone and Sperm. It is used alongside TRT to help maintain fertility and prevent testicular atrophy.
If responsive it allows steroidogenesis to occur where hormones are made from cholesterol in the testes. It allows intra-testicular testosterone(testosterone that is produced in your testes locally) to be produced. This can be reduced with TRT alone. High intra-testicular testosterone is needed to maintain fertility. Studies show when 500IU of HCG is used 2-3 times per week along with exogenous testosterone, in males fertility can be maintained.
In some cases HCG can be used at higher doses as a mono-therapy starting at 500IU every other day and, in rarer cases, as high as 3000IU every other day.
How quickly does TRT work?
Some notice a slight difference after the first injection or application and for others it may take a little longer. Usually energy is the first to come back, but others have mentioned noticing increased morning erections, improvements in mood, and lifting of brain fog.
Female client have reported feeling more assertive and increased sex drive. It’s very individual and making sure your hormones are balanced plays a big part in how quickly TRT will work for you.
What changes will I expect on TRT?
Some people experience increase in mood, energy, erections, sex drive, muscle growth, facial hair growth, body hair growth. Side effects may include mild acne, and some scalp hair loss. It’s all very individual. The majority of people see a massive improvements in symptoms associated with low testosterone.
What happens if TRT doesn’t help/work?
It is important to get blood tests regularly whilst on TRT. Frequent blood testing helps the doctor identify why your treatment may not be providing symptomatic relief. In some cases the doctor may alter your dose, dose frequency or add in ancillary medications to manage other hormone imbalances.
Can I cycle TRT?
TRT works best when it is used continuously. Cycling has connotations with illicit anabolic steroids in bodybuilding and really doesn’t have a place in TRT. Steady stable levels in the optimal range provide the best therapuetic benefits. Ups and downs of cycling may cause harm or frustrate the balance that has been created.
Can I take TRT with other medications?
There are very few contraindications and reactions with TRT and other medications. Our doctors will review your case and determine if any medications you are on will conflict with your existing medications.
Will TRT help with depression?
Testosterone treatment can help with depression. One mechanism of action is through boosting levels of dopamine that correspond with rising levels of testosterone. In a recent study Testosterone therapy was shown to mprove the symptoms of depression.
In a 2004 study by Dr Shores, 278 men aged 45 years old or older found to have low testosterone were 3-4 times more likely to be diagnosed with depression. This indicates a strong link between low testosterone and depression. We know that testosterone can boost neurotransmitters like dopamine. Having a balanced level of testosterone and other hormones like oestrogen and thyroid hormones can help improve depression. According to another study looking at 50 men with an average age of 57 who had low testosterone, 30 of the men were also diagnosed with depression. Of those men only 11 still had symptoms of depression after TRT. So for many men TRT can make a big difference if they have suffering from depression.
Eur Urol Focus. 2018 Jul 14. pii: S2405-4569(18)30172-X. doi: 10.1016/j.euf.2018.07.006.https://www.ncbi.nlm.nih.gov/pubmed/30017901#[Epub ahead of print]Systematic Review of the Impact of Testosterone Replacement Therapy on Depression in Patients with Late-onset Testosterone Deficiency.Vartolomei MD1, Kimura S2, Vartolomei L3, Shariat SF4.
Will TRT help anxiety?
Low testosterone can cause anxiety. Anxiety is multifactorial. Contrary to popular belief anxiety also extremely common. If low testosterone has worsened anxiety then optimising can improve these symptoms. If there are other contributing factors these can also be investigated and treated accordingly examples being talking therapy and counselling in conjunction with TRT, other hormone imbalances or medical issues Some studies have shown men with general anxiety disorder have had improvements with the use of TRT.
BMH clients who experienced anxiety before starting TRT have noticed improvements in their symptoms.
- Wang C, Swerdloff R: Androgen replacement therapy. Ann Med 1997; 29:365–370
- Burris A, Banks S, Carter S, Davidson J, Sherins R: A long-term, prospective study of the physiologic and behavioral effects ohormone replacement in untreated hypogonadal men. J Androl 1992; 13:297–304
- Seidman SN, Rabkin JG: Testosterone replacement therapy forhypogonadal men with SSRI-refractory depression. J Affect Dis-ord 1998; 48:157–161
- Wang C, Alexander G, Berman N, Salshian B, Davidson T, Mc-Donald V, Steiner B, Hull L, Callegari C, Swerdloff RS: Testosterone replacement therapy improves mood in hypogonadal men: a clinical research center study. J Clin Endocrinol Metab 1996; 81:3578–3583
Can I have TRT with antidepressants?
Some anti-depressants can raise levels of prolactin. Hyperprolactinaemia (high prolactin) can be a cause of testosterone deficiency. If taking an anti-depressant, or other medications for that matter, then your TRT doctor will ensure it is suitable to begin TRT alongside these. Many of our clients have worked with their GP and our TRT doctor to wean off the anti-depressants as symptoms improve. Ideally you should not need to have an anti-depressant when on TRT but for some it is preferable, but be sure to consult with your GP or original anti-depressant prescribing doctor, and your Balance My Hormones facilitated doctor to find synergy for you.
One type of anti-depressant or note, should you need it, that has reported very few sexual side effects or raises in prolactin is Bupropion. It is not offered widely in the UK and is also known as the smoking cessation drug ZYBAN. This medication may be beneficial in increasing dopamine and improving mood and may even help you quit smoking. This particular anti-depressant is routinely prescribed as and adjunct outside the UK to offset the negative sexual side effects whilst on an SSRI anti-depressant.
Is there a link between low testosterone and dementia?
A 2018 study looked at low circulating testosterone and the association with dementia. Previous studies were inconsistent. A prospective study was done looking at over 4000 older men who did not have dementia between 71 to 88 years of age. They found that men in the lowest quartiles of calculated free testosterone had an increased risk of developing dementia compared to those in the higher quartile. This study shows an association and further studies may help determine if Testosterone treatment can help ameliorate or prevent the risk of dementia in older men with low testosterone.
Psychoneuroendocrinology. 2018 Aug 9;98:139-147. doi: 10.1016/j.psyneuen.2018.08.013. [Epub ahead of print]Sex hormones and incident dementia in older men: The health in men study.
Ford AH1, Yeap BB2, Flicker L3, Hankey GJ4, Chubb SAP5, Golledge J6, Almeida OP7.
Alzheimers Dement. 2014 Oct;10(5 Suppl):S306-14. doi: 10.1016/j.jalz.2013.06.006. Epub 2013 Sep 10.Low testosterone and the risk of dementia in elderly men: Impact of age and education.
Carcaillon L1, Brailly-Tabard S2, Ancelin ML3, Tzourio C4, Foubert-Samier A5, Dartigues JF5, Guiochon-Mantel A2, Scarabin PY6.
What is prolactin?
Prolactin is a hormone secreted by the pituitary for the purpose of lactation in women and after pregnancy. In men elevated prolactin can be a cause of erectile dysfunction, impotence, and low testosterone. All hormones are needed in the right balance but prolactin is ideal in men between 100-280 mIU/L. Hyperprolactinoma or adenomas are normally seen with levels greater than 5000 mIU/L but can be present at lower levels. Prolactin also is produced in men after orgasm and adds to the refractory period where libido drops, fatigue ensues, and ability to get an erection decreases temporarily.
What causes high prolactin?
When men initially start TRT there may be a transient elevation of prolactin. One reason for this may be due to a decrease in the activity of the pituitary axis. When starting TRT the exogenous testosterone replaces your body’s naturally produced testosterone. This means the signalling from the brain including LH and FSH(gonadotropins) switch off. The lack of this signal corresponds with an elevation of prolactin seen in some men and women in the first 6 months to 1 year on TRT.
Not everyone starting TRT experiences this increase in prolactin due to lack of gonadotropin signalling. The increase in prolactin can also be attributed to rising oestrogen levels, or an underlying hypothyroid issue which may be unmasked when replacing and optimising testosterone levels.
When starting TRT elevations of oestrogen often occur as larger amounts of testosterone are being received into the body. The enzyme aromatase converts testosterone to oestrogen and becomes more active than it was when the man was in a hypogonadal or low testosterone state. The rise of oestrogen from aromatisation of testosterone can cause a rise in prolactin in some men at this point, but does not occur in all men.
Hypothyroidism causes a shut down in the feed back of a hormone signal called TRH (thryoid releasing hormone) which stimulates and enlarges the pituitary. This can stimulate lactotroph (prolactin producing) cells that increase the production and release prolactin.
Other causes of high prolactin may be from certain medications which interfere with the action of dopamine such as:
- Dopamine receptor blockers and antipsychotics
- Dopamine synthesis inhibitors
- Catecholamine depletors
- Heartburn medications both prescription and over the counter such as:
- H2 antagonists- Tagamat®(cimetidine), Zantac®Ranitidine
- Tricyclic antidepressants
- Elavil®(amitriptyline), Asendin®(amoxapine)
- Selective serotonin reuptake inhibitors
- Fluoxetine (Prozac)
- Sertraline etc.
- Calcium channel blockers
- Exogenous and endogenous elevations of Oestrogens
Primary Hypothyroidism with Markedly High Prolactin,Front Endocrinolhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843497/(Lausanne). 2016; 7: 35. Published online 2016 Apr 26. doi: 10.3389/fendo.2016.00035 PMCID: PMC4843497PMID: 27199892 Mohd Saleem Ansari1,* and Mussa H. Almalki1,2
Can elevated prolactin affect my sex drive and ED (erectile dysfunction)?
Elevated prolactin can certainly affect men and women’s sex drive. After ejaculation the levels of dopamine drop and prolactin rises. Normally sleep is induced and there is little desire to ejaculate for some time. The time between desire to ejaculate is known as the refractory period.
Men with longer refractory periods may also be high prolactin producers. Prescription medications that enhance dopamine are called dopamine agonists and can be helpful in lowering levels of prolactin. Many of the dopamine agonists come with side effect of tiredness and fatigue. They are usually of a class called dopamine agonists such as premipexole or roprinole used for Parkinson’s or restless leg syndrome which are the result of diminishing dopamine levels and these drugs help improve the dopamine in the brain.
Cabergoline is a drug that differs from other dopamine agonists. It is an ergot drug which has been approved for use in hyper-prolactinaemia. In small doses taken once or twice per week, cabergoline can lower elevated levels of prolactin, enhance mood, and reduce the refractory period. In one study young healthy males treated with cabergoline demonstrated the ability to have multiple orgasims in quick succession compared with the placebo that required 15-30minutes of rest.
Can TRT help with my ED (erectile dysfunction)?
TRT can help with ED especially when low testosterone is the cause of erectile dysfunction. Some patients are refractory to PDE-5 inhibitors when they have low testosterone. When the testosterone level is optimised PDE-5 inhibitors work even better. The longer you have suffered with low testosterone the longer it may take to reverse the changes caused by chronically low levels. Low testosterone over prolonged periods of time can cause tissue remodelling of the corpus cavernosim (penile shaft). The shaft consist of spongy smooth muscle tissue which can be replaced by collagen if damaged or are exposed to a low testosterone environment. The corpus cavernous structure allows for rigidity in the erect penis by relaxing and engorging with blood. If collagen is present then the engorgement doesn’t happen. Optimising testosterone levels along with PDE-5 inhibitors like tadalifil(Cialis) and Viagra (sildenefil) may help reverse this.
What is Pro-Viron® (PROVIRON) used for?
Proviron is a non-aromatisable androgen that is very similar to the hormone DHT (dihydrotestosterone) which is the metabolite of testosterone. It is used for fertility, and as a monotherapy for TRT in those who have elevated SHGB. It works as an adjunct therapy alongside exogenous testosterone for those with elevated SHGB to bring it back down in range.
Has Proviron been discontinued?
Bayer has confirmed that they have discontinued Pro-Viron® mesterolone in the UK. They would not confirm or could not report that it has been discontinued in other countries. We are looking for alternative options. At the moment our partner pharmacies are trying to secure what is available. The good news is there may be other methods of bringing down stubbornly elevated levels. This includes keep the oestrogen in the optimal range, or using other medications for a short time alongside TRT.
Would it be possible to proceed without the addition of proviron to my treatment? How can I lower SHBG?
If you have high SHBG it could take much longer to lower it with exogenous testosterone alone. Proviron is added as a more aggressive approach, so therapeutic benefit can be reached more efficiently. Nonetheless, it could take several months until your treatment is ‘dialled in’ even with proviron therapy. There are other options for lowering of SHBG. Once lowered often you do not see a rebound in SHGB as the optimal exogenous testosterone can maintain it. We are looking at other options for obtaining Proviron as it has other benefits including improving mood when added to TRT treatments. One way to keep SHGB in check is managing elevated oestrogen. When oestrogen rises SHGB can rise along with it so having an aromatase inhibitor like anastrozole or exemestane alongside TRT can help bring down these levels.