Low Dose Naltrexone (LDN)

Low Dose Naltrexone (LDN) – A New Option for Hormone Optimisation Patients

At Balance My Hormones, we work with patients who are exploring a range of therapies to optimise their health and wellbeing. One treatment that is gaining attention is Low-Dose Naltrexone (LDN). Originally developed in higher doses for other uses, at much smaller doses it is being researched for its role in supporting immune regulation, inflammation pathways, and general wellbeing.

What is Low-Dose Naltrexone?

LDN typically refers to daily doses between 0.5mg – 4.5mg, far lower than standard prescribing.
Researchers are investigating how these smaller doses interact with the body’s natural opioid and endorphin systems.
Patients and clinicians worldwide are exploring its potential in areas such as pain, mood, immune balance, and recovery.

Why is LDN Relevant to TRT and HRT Patients?

Many patients undergoing testosterone replacement therapy (TRT) or hormone replacement therapy (HRT) want to support not just their hormone levels, but also their overall health and resilience. LDN may have a role as part of a broader wellbeing plan:

Supporting Immune Balance

Research is ongoing into how LDN may modulate immune system activity, which is of interest to patients aiming to stay healthy while on long-term therapies.

Inflammatory Pathways

Chronic inflammation is linked with ageing and hormone imbalance. Early studies suggest LDN could play a part in supporting anti-inflammatory balance.

Mood and Resilience

Some patients on TRT or HRT report challenges with mood during dose adjustments. LDN is being investigated for its role in endorphin signalling, which may support emotional wellbeing.

Metabolic Health

Hormone optimisation often goes hand-in-hand with weight management, exercise, and lifestyle changes. LDN has been studied in the context of appetite, metabolism, and energy regulation.

Important to Know

LDN is considered an unlicensed medicine in the UK and can only be prescribed where a doctor decides it is appropriate for an individual patient.
The evidence base is still developing. While many patients find it of interest, more research is needed to establish its full benefits and long-term safety.
At Balance My Hormones, any use of LDN would always be under the supervision of a qualified prescriber, as part of a personalised care plan.

How to Get Low Dose Naltrexone

If you are a patient already on TRT or HRT and would like to explore whether Low-Dose Naltrexone may complement your treatment, speak to your Balance My Hormones case manager. A doctor will carefully review your medical history and determine whether this treatment may be appropriate for you.

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