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The Truth On Sustanon Injections And Side Effects

Sustanon one of many options of injectable testosterone in the UK, also known as Sustanon 250, is an oil-based injectable consisting of four different testosterone esters: testosterone propionate (30mg), testosterone phenylpropionate (60mg), testosterone isocaproate (60mg) and tesosterone decanoate (100mg).

Sustanon injections were originally developed for patients to receive the fast-acting benefits of testosterone over an extended period. The idea of using a combination of short and long duration esters was for people to be able to inject every 2-3 weeks.

More recently, Sustanon has become popular in bodybuilding circles for its androgenic properties and sustained release of testosterone. Although, Sustanon is not available for prescription in the United States and is only available on the black market there. However, In the UK and Europe, Sustanon is available by prescription.

Almost all TRT literature from the US (the biggest market for TRT) focuses on testosterone enanthate, cypionate and propionate. As such, patients diagnosed with low testosterone in the UK may be wary of treatment with Sustanon because of its reputation as a ‘designer steroid.’


The Truth About Sustanon Injections

The combination of four different esters in Sustanon gives it a higher perceived value in the eyes of many people. In truth however, Sustanon has the same effects and benefits as other testosterone preparations.

As mentioned, the intention of Sustanon was for people to  inject every 2-3 weeks. This sounds great in practice – less needles means less hassle right? Sadly not. This type of injection frequency inevitably produces what Sustanon was meant to prevent: Peaks and valleys in blood testosterone levels.

This is because the half life , i.e. the time period required for the concentration of a drug in the body be reduced to one half, of the testosterone esters in Sustanon vary from 2 days to 2 weeks. So over the course of 2-3 weeks, blood testosterone levels will drop.

Therefore, the recommendation is to inject Sustanon every 5 days. This ensures you maintain stable blood testosterone levels and avoid the peaks and valleys of low frequency Sustanon injections.

The manufacturer of Sustanon produce it in glass ampoules. Therefore, they are not as easy to use as the re-usable vials seen in the US. It does take some practice, however once you know how to do it the process is straightforward.

Sustanon Side Effects in Testosterone Replacement Therapy

As a direct testosterone product, Sustanon has the same side effects as other testosterone preparations.

There are two types of side effects that you should consider with testosterone replacement therapy. The first are estrogenic side effects, these include:

  • Water retention / puffiness
  • Bloating
  • Sensitive nipples
  • Mood swings
  • Gynecomastia

it may be necessary for some patients undergoing TRT to take an anti-estrogen such as a Arimidex or Aromasin to curtail estrogenic side effects.

You must also consider the androgenic side effects of Sustanon/TRT, they include:

  • Acne
  • Oily skin
  • Body and facial hair growth
  • Male pattern baldness (for those predisposed to baldness)

Sustanon, as with any other form of testosterone, will produce negative side effects when taken in non-clinical/surpraphysiological doses. However, proper dosage and regular injection frequency will mitigate virtually all side effects. Therefore, it is of critical importance to always seek treatment from a reputable doctor.

Remember, testosterone is a fundamental hormone to the human body. And so the body readily accommodates it:

Bio-identical testosterone is NOT the same as a synthetic steroid that is a derivative of the testosterone molecule.

Final Thoughts

When used properly, Sustanon is an option for testosterone replacement therapy.

Some NHS doctors in the UK avoid Sustanon due to concerns with peaks and valleys when injecting every 2-3 weeks.  However, they miss the point entirely.

Unfortunately, the lack a basic understanding of pharmacology and ester half lives. Therefore, they prefer to prescribe Nebido under the false impression it’s more stable than Sustanon. Or perhaps they like the fact that patients need to inject less with it, either way it’s the patient that suffers.

The experience of Sustanon both personally and with patients has been very positive.  Almost like clockwork, the combination of esters means you can accurately predict blood levels of testosterone. This makes it a very reliable method for testosterone replacement.

It must be noted that individuals with a peanut allergy should not consider Sustanon because it contains peanut oil.

If you want to discuss the potential options for testosterone replacement therapy, get in contact with us today.

**Please note the information on this page is not intended to promote prescription only medications. We are not providing medical advice and are not a provider of medical care nor do we make any claims. The information on this page is not meant to be a substitute for medical advice provided by your healthcare practioner. Please consult with your doctor should you have any questions or contact us to arrange a proper consulation with an independent doctor provider. The informaiton on this page may not necessarily reflect the views of all doctors in our network. **


Evidence Based Research

This article has been researched and written based on scientific evidence and fact sheets that have then been crossed checked by our team of doctors and subject matter experts.

References, sources and studies used alongside our own in-house research have been cited below, most of which contain external clickable links to reviewed scientific paper that contain date stamped evidence.

Our team of healthcare experts and GMC registered doctors are licensed to UK GMC standards. We strive to provide you with the latest evidence based, researched articles that are unbiased, honest and provide you with accurate insights, statistics and helpful information on the discussed topic to ensure you gain a better understanding of the subject.

We value your feedback on our articles, if you have a well-researched paper you would like to share with us please contact us.

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About the Author: Mike Kocsis

Mike Kocsis has an MBA with a focus on healthcare administration and is an entrepreneur and medical case manager for Balance My Hormones Ltd which offers medical services in the UK and Europe. Mike has over 20 years of experience in the healthcare sector, much of that working with people who have hormone imbalances. Mike has appeared on podcasts and radio and is an expert speaker on the subject of hormone imbalance. He specialises in Testosterone Replacement Therapy (TRT) and Hormone Replacement Therapy (HRT) and has helped thousands of people suffering from hormone imbalances recover and regain control of their lives. You can follow him on LinkedIn and on the Balance My Hormones YouTube Channel.

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Last update: March 25th, 2021

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